Center for Pharmacogenomics and Precision Medicine

Mission

Our mission is to facilitate the clinical implementation of precision medicine by improving patient outcomes through the optimization of efficacy and limiting toxicity of drug therapy. This is accomplished through research, teaching and service focused on genetically-guided therapeutic decision-making, drug discovery and drug development.

Goals

  • Enhance the quality of precision medicine through pharmacogenomics research
    • Bring together faculty working in the precision medicine field and increase multidisciplinary collaboration among faculty
    • Provide genotyping, gene expression, DNA methylation, and analytical services to the UF community and beyond
  • Provide an environment for training clinical and translational scientists in pharmacogenomics
  • Educate the UF Health community on pharmacogenomics

Services

Pharmacogenomic laboratory and analytical services are provided for UF and non-UF investigators through the CPPM Core Laboratory. Services are provided either as a price per sample or price per project depending on the service type and specific needs of the researcher. Researchers interested in multiple services will be provided with an estimate of the charges for the entire project. We strive to accommodate the needs of each researcher; if you do not see a service listed on our menu, please inquire.


Leadership

Co Directors

Larisa H Cavallari
Department: Pharmacotherapy & Translational Research

Larisa H Cavallari Pharm.D., BCPS, FCCP

Professor And Debbie DeSantis Term Professor
Phone: (352) 273-8245
Julio D Duarte
Department: Pharmacotherapy & Translational Research

Julio D Duarte Pharm.D., Ph.D., FAHA

Associate Professor
Phone: (352) 273-8132

Affiliated Faculty | Research Interests

Professor and the Debbie DeSantis Term Professor in the UF College of Pharmacy

Larisa Cavallari, Pharm.D.

* Effectiveness of cardiovascular drugs
* Dose requirements of warfarin
* Opioid effectiveness and toxicity
* Drug metabolism enzyme activity and expression
* Outcomes with clinical implementation of genotype-guided therapy

Cavallari 600x400

Research Assistant Professor

Joseph Collins, Ph.D.

* Epigenetic and genetic variation contributing to differences in pharmacogene expression
* Computational approaches to utilize public datasets for variant discovery and validation

Dr. Joseph Collins

Associate Professor

Julio Duarte, Pharm.D., Ph.D.

* Effectiveness of cardiovascular drugs
* Genomics to identify novel drug targets for cardiopulmonary diseases
* Outcomes with clinical implementation of genotype-guided therapy

Julio Duarte

Associate Professor

Yan Gong, Ph.D.

* Effectiveness of cardiovascular drugs
* Cardiotoxic response to cancer treatments (Cardio-Oncology)
* Adverse drug response to antiresorptive drugs

Yan Gong

Associate Dean For Research And Graduate Education; Professor And The Frank A. Duckworth Eminent Scholar Chair

Jatinder Lamba, Ph.D., M.Sc.

* Cancer treatment outcomes
* Toxicity to anti-leukemic agents
* CRISPR/cas9 mediated genetic perturbation screening in cancer
* Development of genomics guided immunotherapy for treatment of leukemia
* Systems biology approaches using multi-dimensional data to establish prognostic markers in cancer

Jatinder Lamba

Assistant Professor

Caitrin McDonough, Ph.D., M.S.

* Effectiveness of cardiovascular drugs
* Predisposition to adverse cardiovascular and cerebrovascular outcomes and high risk disease
* Development of multi-dimensional data models for cardiovascular disease identification and prediction
* Development of multi-dimensional data models for Alzheimer’s Disease and Related Dementias

Caitrin McDonough

Clinical Assistant PRofessor

Khoa Nguyen, Pharm.D.

* Effectiveness of cardiovascular drugs
* Opioid effectiveness and toxicity
* Outcomes with clinical implementation of genotype-guided therapy

Khoa Nguyen

Associate Professor

Luisel Ricks-Santi, Ph.D.

* Cancer treatment options
* Predisposition to aggressive breast and prostate cancer
* Genetic basis of cancer disparities
* Outcomes with clinical implementation of genotype-guided therapy

Dr. Ricks-Santi

Research Assistant Professor

Marwa Tantawy, Ph.D.

* Cardiotoxic response in cancer treatment (Cardio-oncology)
* Pharmacogenomics and personalized medicine
* iPSC differentiation for mechanistic insights into cardiovascular complications

Marwa Tantawy


Policies and Forms

Download policies and forms related to the Center for Pharmacogenomics and Precision Medicine

PTR graduate student