Center for Pharmacogenomics and Precision Medicine

Research in the Center for Pharmacogenomics and Precision Medicine spans from mechanistic studies to multi-omic approaches to elucidate genetic contributions to drug response. Center investigators collaborate with investigators across the University of Florida and other institutions, both nationally and internationally, to ensure innovation in this cutting-edge science. The center also supports the UF Health Precision Medicine Program through the translation of pharmacogenomic research findings into patient care and examining outcomes with genotype-guided therapies.

Mission

Our mission is to facilitate precision medicine by improving patient outcomes through optimization of efficacy and limiting toxicity of drug therapy. This is accomplished through research, teaching and service focused on genetically-guided drug therapy decision making, drug discovery and drug development.

Goals

Leadership

director

Larisa Cavallari, Pharm.D., FCCP, BCPS

Professor of Pharmacotherapy and Translational Research and the Debbie DeSantis Term Professor in the UF College of Pharmacy

Cavallari 600x400

associate director

Julio Duarte, Pharm.D., Ph.D., FAHA

Assistant Professor of Pharmacotherapy and Translational Research in the UF College of Pharmacy

Duarte, Julio

director of genotyping core lab

Taimour Langaee, MSPH, Ph.D.

Research Professor of Pharmacotherapy and Translational Research in the UF College of Pharmacy

Langaee, Taimour

Meet Our Faculty

Dominick J Angiolillo

Dominick J Angiolillo

Chief, Division Of Cardiology; Medical Director, UF Health Cardiovascular Center – Jacksonville; Medical Director, Cardiovascular Research Program; Program Director, Interventional Cardiology Fellowship
Department: Medicine – Jacksonville
Emily J Cicali

Emily J Cicali Pharm.D.

Clinical Assistant Professor
Department: Pharmacotherapy & Translational Research
Rhonda M Cooper-DeHoff

Rhonda M Cooper-DeHoff Pharm.D., M.S., FAHA, FACC, FCCP

Associate Professor
Department: Pharmacotherapy & Translational Research
David DeRemer

David DeRemer Pharm.D., BCOP, FCCP, FHOPA

Clinical Associate Professor
Department: Pharmacotherapy & Translational Research
Reginald Frye

Reginald Frye Pharm.D., Ph.D., FCCP

Associate Dean For Faculty Development; Professor And Chair
Department: Pharmacotherapy & Translational Research
Yan Gong

Yan Gong Ph.D.

Associate Professor
Department: Pharmacotherapy & Translational Research
Julie A Johnson

Julie A Johnson Pharm.D.

Dean & Distinguished Professor
Department: Dean's Office
Awewura Kwara

Awewura Kwara MD, MB, ChB, MPH, TM

Professor Of Medicine, VA Section Chief
Department: MD-INFECTIOUS DISEASES
Jatinder Lamba

Jatinder Lamba Ph.D., M.Sc.

Professor, Graduate Coordinator And The Frank A. Duckworth Eminent Scholar Chair
Department: Pharmacotherapy & Translational Research
John S Markowitz

John S Markowitz Pharm.D., BCPP

Professor
Department: Pharmacotherapy & Translational Research
Caitrin W McDonough

Caitrin W McDonough Ph.D., M.S.

Assistant Professor
Department: Pharmacotherapy & Translational Research
Khoa A Nguyen

Khoa A Nguyen Pharm.D.

Clinical Assistant Professor
Department: Pharmacotherapy & Translational Research
Luisel Ricks-Santi

Luisel Ricks-Santi Ph.D.

Associate Professor
Department: Pharmacotherapy & Translational Research
Nathan D Seligson

Nathan D Seligson Pharm.D.

Clinical Assistant Professor
Department: Pharmacotherapy & Translational Research
Danxin Wang

Danxin Wang M.D., Ph.D.

Associate Professor
Department: Pharmacotherapy & Translational Research
Kristin Wiisanen

Kristin Wiisanen Pharm.D., FAPhA, FCCP

Clinical Professor And Associate Dean For Entrepreneurial Programs; Associate Director Of The UF Health Precision Medicine Program; Director Of The Graduate Program In Precision Medicine
Department: Entrepreneurial Programs

Areas of Research

Genetic variability influencing:

Effectiveness of cardiovascular drugs

Dominick Angiolillo
Larisa Cavallari
Rhonda Cooper-DeHoff
Julio Duarte
Yan Gong
Julie Johnson
Caitrin McDonough
Khoa Nguyen

Genetic variability influencing:

Dose requirements of warfarin

Larisa Cavallari
Julie Johnson

Genetic variability influencing:

Opioid effectiveness and toxicity

Larisa Cavallari
Julie Johnson
Khoa Nguyen

Genetic variability influencing:

Cancer treatment outcomes

David DeRemer
Jatinder Lamba
Luisel Ricks-Santi
Nathan Seligson

GENETIC VARIABILITY INFLUENCING:

Toxicity to anti-leukemic agents

Jatinder Lamba

GENETIC VARIABILITY INFLUENCING:

Cardiotoxic response to cancer treatments (Cardio-Oncology)

David DeRemer
Yan Gong

GENETIC VARIABILITY INFLUENCING:

Drug metabolism enzyme activity and expression

Larisa Cavallari
Emily Cicali
Reginald Frye
Julie Johnson
John Markowitz
Danxin Wang

GENETIC VARIABILITY INFLUENCING:

Drug transporter activity

Reginald Frye
John Markowitz

GENETIC VARIABILITY INFLUENCING:

Response to treatment for HIV, TB, and HBV and other infectious diseases

Awe Kwara
Taimour Langaee

GENETIC VARIABILITY INFLUENCING:

Response to dichloroacetate treatment in children with lactic acidosis

Taimour Langaee

GENETIC VARIABILITY INFLUENCING:

Adverse drug response to antiresorptive drugs

Yan Gong

Genomics to identify novel drug targets for cardiopulmonary diseases

Julio Duarte

CRISPR/cas9 mediated genetic perturbation screening in cancer

Jatinder Lamba

Development of genomics guided immunotherapy for treatment of leukemia

Jatinder Lamba

Systems biology approaches using multi-dimensional data to establish prognostic markers in cancer

Jatinder Lamba
Nathan Seligson

Predisposition to aggressive breast and prostate cancer

Luisel Ricks-Santi

Genetic basis of cancer disparities

Luisel Ricks-Santi

Outcomes with clinical implementation of genotype-guided therapy

Larisa Cavallari
Emily Cicali
Rhonda Cooper-DeHoff
Julio Duarte
Julie Johnson
Khoa Nguyen
Luisel Ricks-Santi
Kristin Wiisanen

Genotype Services

Genotyping services are provided for investigators within and outside of the University of Florida through the Center for Pharmacogenomics and Precision Medicine Genotyping Core Laboratory. Services are provided either as a price per sample or price per project depending on the specific needs of the researcher. Basic “a la carte” services, such as DNA isolation and quantitation are performed at a price per sample rate listed below. Researchers interested in multiple services will be provided with an estimate of charges for the entire project. We strive to accommodate the needs of each researcher; if you do not see a service listed on our menu, please inquire.

GENOTYPING

Services, Platforms and Pricing

Review our services, state-of-the-art technology and pricing for genotype services.

Contact Us

Center for Pharmacogenomics and Precision Medicine
University of Florida College of Pharmacy
P.O. Box 100486
Gainesville, FL 32610

lcavallari@cop.ufl.edu
352-273-5283

Genotyping Core Laboratory
Center for Pharmacogenomics and Precision Medicine
Taimour Y. Langaee, MSPH, Ph.D.
Research Professor

langaee@cop.ufl.edu
352-273-6357