Research in the Center for Pharmacogenomics and Precision Medicine spans from mechanistic studies to multi-omic approaches to elucidate genetic contributions to drug response. Center investigators collaborate with investigators across the University of Florida and other institutions, both nationally and internationally, to ensure innovation in this cutting-edge science. The center also supports the UF Health Precision Medicine Program through the translation of pharmacogenomic research findings into patient care and examining outcomes with genotype-guided therapies.
Mission
Our mission is to facilitate precision medicine by improving patient outcomes through optimization of efficacy and limiting toxicity of drug therapy. This is accomplished through research, teaching and service focused on genetically-guided drug therapy decision making, drug discovery and drug development.
Goals
- Enhance the quality of precision medicine through pharmacogenomics research at the University of Florida
- Bring together faculty working in this field and increasing multidisciplinary collaboration among faculty
- Provide genotyping and other services (e.g. gene expression, methylation) to the UF community and beyond
- Provide an environment for training clinical and basic scientists in pharmacogenomics
- Educate the UF Health community on pharmacogenomics
Leadership
director
Larisa Cavallari, Pharm.D., FCCP, BCPS
Professor of Pharmacotherapy and Translational Research and the Debbie DeSantis Term Professor in the UF College of Pharmacy
associate director
Julio Duarte, Pharm.D., Ph.D., FAHA
Assistant Professor of Pharmacotherapy and Translational Research in the UF College of Pharmacy
director of genotyping core lab
Taimour Langaee, MSPH, Ph.D.
Research Professor of Pharmacotherapy and Translational Research in the UF College of Pharmacy
Meet Our Faculty
Dominick J Angiolillo M.D., Ph.D., FACC
Emily J Cicali Pharm.D.
Rhonda M Cooper-DeHoff Pharm.D., M.S., FAHA, FACC, FCCP
David DeRemer Pharm.D., BCOP, FCCP, FHOPA
Reginald Frye Pharm.D., Ph.D., FCCP
Yan Gong Ph.D.
Julie A Johnson Pharm.D.
Awewura Kwara MD, MB, ChB, MPH, TM
Jatinder Lamba Ph.D., M.Sc.
John S Markowitz Pharm.D., BCPP
Caitrin W McDonough Ph.D., M.S.
Khoa Nguyen Pharm.D.
Luisel Ricks-Santi Ph.D.
Nathan D Seligson Pharm.D.
Danxin Wang M.D., Ph.D.
Kristin Wiisanen Pharm.D., FAPhA, FCCP
Areas of Research
Genetic variability influencing:
Effectiveness of cardiovascular drugs
Dominick Angiolillo
Larisa Cavallari
Rhonda Cooper-DeHoff
Julio Duarte
Yan Gong
Julie Johnson
Caitrin McDonough
Khoa Nguyen
Genetic variability influencing:
Dose requirements of warfarin
Larisa Cavallari
Julie Johnson
Genetic variability influencing:
Opioid effectiveness and toxicity
Larisa Cavallari
Julie Johnson
Khoa Nguyen
Genetic variability influencing:
Cancer treatment outcomes
David DeRemer
Jatinder Lamba
Luisel Ricks-Santi
Nathan Seligson
GENETIC VARIABILITY INFLUENCING:
Toxicity to anti-leukemic agents
Jatinder Lamba
GENETIC VARIABILITY INFLUENCING:
Cardiotoxic response to cancer treatments (Cardio-Oncology)
David DeRemer
Yan Gong
GENETIC VARIABILITY INFLUENCING:
Drug metabolism enzyme activity and expression
Larisa Cavallari
Emily Cicali
Reginald Frye
Julie Johnson
John Markowitz
Danxin Wang
GENETIC VARIABILITY INFLUENCING:
Drug transporter activity
Reginald Frye
John Markowitz
GENETIC VARIABILITY INFLUENCING:
Response to treatment for HIV, TB, and HBV and other infectious diseases
Awe Kwara
Taimour Langaee
GENETIC VARIABILITY INFLUENCING:
Response to dichloroacetate treatment in children with lactic acidosis
Taimour Langaee
GENETIC VARIABILITY INFLUENCING:
Adverse drug response to antiresorptive drugs
Yan Gong
Genomics to identify novel drug targets for cardiopulmonary diseases
Julio Duarte
CRISPR/cas9 mediated genetic perturbation screening in cancer
Jatinder Lamba
Development of genomics guided immunotherapy for treatment of leukemia
Jatinder Lamba
Systems biology approaches using multi-dimensional data to establish prognostic markers in cancer
Jatinder Lamba
Nathan Seligson
Predisposition to aggressive breast and prostate cancer
Luisel Ricks-Santi
Genetic basis of cancer disparities
Luisel Ricks-Santi
Outcomes with clinical implementation of genotype-guided therapy
Larisa Cavallari
Emily Cicali
Rhonda Cooper-DeHoff
Julio Duarte
Julie Johnson
Khoa Nguyen
Luisel Ricks-Santi
Kristin Wiisanen
Genotype Services
Genotyping services are provided for investigators within and outside of the University of Florida through the Center for Pharmacogenomics and Precision Medicine Genotyping Core Laboratory. Services are provided either as a price per sample or price per project depending on the specific needs of the researcher. Basic “a la carte” services, such as DNA isolation and quantitation are performed at a price per sample rate listed below. Researchers interested in multiple services will be provided with an estimate of charges for the entire project. We strive to accommodate the needs of each researcher; if you do not see a service listed on our menu, please inquire.
GENOTYPING
Services, Platforms and Pricing
Review our services, state-of-the-art technology and pricing for genotype services.