CYP2D6 Phenoconversion Calculator

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The PROP™ Pharmacogenetics Calculator is intended to help clinicians integrate a standardized method of assessing CYP2D6 phenoconversion into practice when a CYP2D6 genotype is available. The CYP2D6 drug metabolizing enzyme is susceptible to inhibition by concomitant drugs, which can lead to a clinical phenotype that is different from the genotype-based phenotype, a process referred to as phenoconversion. Phenoconversion is highly prevalent but not widely integrated into practice because of either limited experience on how to integrate or lack of knowledge that it has occurred.

Use this calculator to enter a patient’s CYP2D6 genotype and choose any interacting medications and the patient’s activity score and clinical phenotype will be displayed. This calculator uses updated recommendations for translating CYP2D6 genotype to phenotype from the Clinical Pharmacogenetics Implementation Consortium (CPIC) and includes drugs classified as strong or moderate CYP2D6 inhibitors by the Food and Drug Administration. For complete information on how the calculator was developed, see Cicali EJ, et al., How to Integrate CYP2D6 Phenoconversion into Clinical Pharmacogenetics: A Tutorial. Clin Pharmacol Ther. 2021 Jul 7. doi: 10.1002/cpt.2354. Epub ahead of print. PMID: 34231197.

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