If either TPMT or NUDT15 genotypes are unavailable, scroll down to “Instructions for Unavailable Genotypes”.
Important Instructions: Please select the appropriate NUDT15 phenotype from the list below and then use TPMT phenotype to select the appropriate recommendation.
- NUDT15 Normal Metabolizer
- NUDT15 Intermediate Metabolizer
- NUDT15 Poor – Intermediate Metabolizer
- NUDT15 Poor Metabolizer
Instructions for Unavailable Genotypes
If for NUDT15 either Assay Failure, Unable to Genotype, or Unknown Phenotype are resulted or NUDT15 was not genotyped, but TPMT is available, utilize the NUDT15 Normal Metabolizer page and select the appropriate TPMT phenotype for the recommendation. These recommendations may be affected by the patient’s unavailable NUDT15 genotype; consider testing or repeat testing of NUDT15 as appropriate.
If for TPMT either Assay Failure, Unable to Genotype, or Unknown Phenotype are resulted or TPMT was not genotyped, but NUDT15 is available, select the appropriate page above based on NUDT15 phenotype and then utilize the recommendation for TPMT Normal Metabolizer phenotype. These recommendations may be affected by the patient’s unavailable TPMT genotype; consider testing or repeat testing of TPMT as appropriate.
Unable to Genotype or Assay Failure
- The analysis failed to yield an informative result and thus no genotype is reported.
Unknown Phenotype
- This individual is carrying at least one allele with uncertain/unknown function and the predicted phenotype cannot be determined at this time.
Reference
- Relling MV et al. Clin Pharmacol Ther. 2019 May;105(5):1095-1105. PMID: 30447069.