SLCO1B1, ABCG2 and Rosuvastatin: SLCO1B1 Increased Function

Increased SLCO1B1 transporter function. Normal myopathy risk expected based on SLCO1B1 alone.

Important Instructions: Please use ABCG2 phenotype to select the appropriate recommendation below.

ABCG2 Normal Function

Normal ABCG2 transporter function. Normal response expected based on ABCG2 alone.

Therapeutic Recommendation

  • Initiate standard dosing.

ABCG2 Decreased Function

Decreased ABCG2 transporter function. Increased chance for treatment success (i.e., lipid-lowering) based on ABCG2 alone.

Therapeutic Recommendation

  • Initiate standard dosing.

ABCG2 Poor Function

Little ABCG2 transporter function. Increased chance for treatment success (i.e., lipid-lowering) and potential risk for myopathy secondary to increased drug exposure based on ABCG2 alone.

Therapeutic Recommendation

  • Initiate ≤ 20 mg, if dose > 20 mg is needed, consider alternative statin or combination therapy.

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