CYP2C9, VKORC1, rs12777823 (CYP2C Cluster) and Warfarin

Genotype information can be utilized along with clinical information to guide initial warfarin dosing and predict a patient’s stable daily warfarin dose. Utilize the flowchart below to determine which warfarin algorithm should be used and additional modifications warranted.*

Adults

Pediatric

*Note: This flow chart has been adapted from CPIC guidelines to reflect a pharmacogenetics panel that includes CYP2C9 *2,*3,*5,*6,*8,*11, VKORC1 1639G>A, and rs12777823(CYP2C Cluster). If you have results that include different variants, please follow the link to the CPIC guideline below to utilize the full flowchart.

Reference

  • Johnson JA et al. Clin Pharmacol Ther. 2017 Sep;102(3):397-404. PMID: 28198005.

Resources