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CYP2D6 and CYP2C19 variability: Increased antidepressant trials, side effects?

Published: May 7th, 2014

In a retrospective analysis of individuals with obsessive-compulsive disorder (OCD) previously treated with multiple trials of antidepressants, neither CYP2D6 nor CYP2C19 metabolism status was associated with overall differences in duration […]

Irinotecan ADRs predicted by UGT1A1*28 polymorphisms

Published: May 1st, 2014

A recent meta-analysis revealed up to a 4-fold increase in the risk of neutropenia in patients with a polymorphisms in the UGT1A1 enzyme who were treated with irinotecan (Camptosar, Pfizer), […]

Factors influencing physician adoption of genome-guided prescribing

Published: Mar 24th, 2014

According to a survey administered to 101 internal medicine physicians practicing in an academic medical center, few clinicians are aware of genome-guided prescribing practices, although the majority of respondents felt […]