Factors influencing physician adoption of genome-guided prescribing

Published: March 24th, 2014

Category: Stories

According to a survey administered to 101 internal medicine physicians practicing in an academic medical center, few clinicians are aware of genome-guided prescribing practices, although the majority of respondents felt this information was useful. Lack of awareness of and experience with genome-guided medicine were identifies as barriers to adoption of genome-guided prescribing.

Main Points

In the current article, investigators surveyed physicians from the Icahn School of Medicine at Mount Sinai to determine attitudes toward genome-informed practices and clinical decision support.  Researchers used two survey instruments to assess physician opinions of genome-guided prescribing, personal genome testing, and individual comfort level with technology. Content and face validity of the survey instrument was assessed by a panel of clinical, genomics, and informatics experts.

A total of 101 internal medicine physicians (88% residency program trainees) completed the surveys between August 2012 and June 2013 in conjunction with seven 1-hour educational programs.

Survey results indicated that few physicians were aware of genome-guided prescribing, although the majority supported this information as being useful. Although most respondents felt comfortable using technology, lack of awareness and experience were identified as barriers in adopting genome-guided medicine.

Clinical Implications

Survey results shed light on barriers to adopting genomic-guided prescribing through clinical decision support. With rapidly advancing genomic information, it is important for physicians to understand how to interpret and apply this information for optimal patient care. Physicians are encouraged to seek genomics education and training to facilitate genomic-guided medicine practices.


Overby CL, et al. Physician attitudes toward adopting genome-guided prescribing through clinical decision support. J Personalized Med. 2014;4:35-49.